Effect of indomethacin on tumor invasion in human laryngeal cancer Hep-2 cells |
| |
| Authors: | GAO Yu WANG Ji-qun SHAN Yan-chun |
| |
| Institution: | 1. Department of Otolaryngology, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, China;
2. Medical College of Jinan University, Guangzhou 510632, China |
| |
| Abstract: | AIM: To assess the effect of indomethacin on tumor invasion in a human laryngeal cancer Hep-2 cell line in vitro. METHODS: Hep-2 cells were exposed to indomethacin at different concentrations for 48 h. Then cell growth rate, the colony formation in soft agar medium and cell mobility were examined, and monolayer invasion assay was performed to assess cell invasion index. RESULTS: Preteatment with indomethacin inhibited the colony formation of Hep-2 cells and the cell mobility, and decreased the invasion index. CONCLUSION: Indomethacin can inhibit the invasion of Hep-2 cells. |
| |
| Keywords: | Laryngeal neoplasms Indomethacin Neoplasm invasiveness Hep-2 cells |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
