Detection of serum MDA,NO and INOS in patients with SARS andits clinical significance |
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| Authors: | WU Xin-zhong HUANG Xian-zhang KE Pei- feng ZHENG Song-bo MA Yan ZHUANG Jun-hua LIN Lin ZOU Guo -lin |
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| Institution: | 1. College of Life Science, Wuhan University , Wuhan 430072, China;
2. Department of Laboratory Science, Guangdong Province Hospital of TCM, Guangzhou 510105, China;
3. Department of Respiratory, Guangdong Province Hospital of TCM, Guangzhou 510105, China |
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| Abstract: | AIM: To observe free radicals (MDA, NO) and iNOS of patients with severe acute respiratory syndrome (SARS) and to explore its significance. METHODS: MDA, NO2-/NO3- and iNOS were determined in SARS patients during the early, recovery and follow-up stage, front doctors and nurses (contact group) and health people (health control). RESULTS: The level of MDA during first stage was higher than that of recovery stage and the MDA level of recovery stage was higher than that of follow-up stage, contact group, and health control group (P<0.01). The content of NO2-/NO3- during early stage was higher than that of other groups, and the NO2-/NO3- contents of recovery stage, follow-up stage were higher than that of contact group and health control group (P<0.01), respectively. The mean of iNOS during early stage was highest than that of other stages (P<0.01) and the mean of recovery stage was higher than that of contact group (P<0.05), there were no difference in iNOS activity among any other groups (P>0.05). CONCLUSION: The pathological injury in pathogenesis of SARS is related to free radicals. |
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| Keywords: | Severe acute respiratory syndrome Malondiadehyde Nitric oxide Nitric-oxide synthase |
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