Antioxidant status and oxidatvie damage in patients with Graves' disease |
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| Authors: | SUN Wei-ming TANG Xu-lei LIU Xiao-ju ZHAO Jin LIU Wei |
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| Institution: | 1. Department of Endocrinology, The First Affiliated Hospital, Lanzhou Medical College, Lanzhou 730000, China;
2. Department of Respiratory Medicine, The First Affiliated Hospital, Lanzhou Medical College, Lanzhou 730000, China;
3. Medical College, Northwest Minorities University, Lanzhou 730030, China |
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| Abstract: | AIM: To investigate the antioxidant status and the oxidative damage of cellular macromolecules in patients with Graves' disease. METHODS: Fasting plasma level of total antioxidant capacity (TAC), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in 31 patients with untreated Graves' disease and 31 treated Graves' disease. DNA damage of peripheral blood mononuclear cell (PBMC) was detected by single cell gel electrophoresis assay (expressed in comet percentage). In addition, thiol group (SH) and malondialdehyde (MDA) were measured. 31 age-matched healthy subjects were studied as a control group. RESULTS: Plasma TAC, SOD and GSH-Px were significantly lower in patients with untreated Graves' disease compared to the controls (P＜0.05, P＜0.01). The comet percentage of PBMC and the content of MDA in plasma from patients with untreated Graves' disease were significantly higher than those from the controls (P＜0.01), whereas the level of SH was decreased in patients with untreated Graves' disease (P＜0.01). Threatment with methimazole led to an improvement in oxidative damage indices and antioxidant potential parameters. But they still did not turn to normal. The comet percentage of PBMC was negatively correlated with the level of TAC (r＝-0.599, -0.429, P＜0.01, P＜0.05); and was positively correlated with the level of MDA (r＝0.463, 0.402, P＜0.01, P＜0.05) in Graves' disease. CONCLUSION: The oxidation-antioxidation imbalance and the oxidative damage of cellular macromolecules are involved in the pathogenesis of Graves' disease. |
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| Keywords: | Graves' disease Oxidative stress Malondialdehyde DNA damage |
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