Effect of propolis on the expression of CD54 and activation of NF-κB p65 of lung tissue in acute lung injury rats |
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| Authors: | HU Fu-liang CHEN Min-li LI Ying-hua ZHU Wei YING Hua-zhong |
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| Institution: | 1. College of Animal Sciences, Zhejiang University, Hangzhou 310029, China;
2. College of Zhejiang Traditional Chinese Medicine, Hangzhou 310053, China |
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| Abstract: | AIM: To study the effect of propolis on the expression of CD54 and activation of NF-κB p65 in lung tissue of acute lung injury (ALI) rats. METHODS: 40 male Wistar rats were divided into 5 groups: normal control, model control, dectancyl group, water soluble derivative of propolis (WSP) group and ethanol extracted propolis (EEP) group. ALI animal model was performed by oleic acid and LPS twice attack. The pathologic slice was observed with light microscope and the NF-κB p65 activity and CD54 expression were tested by immunohistochemistry (SABC and SP). RESULTS: Both EEP and WSP antagonized the lung edema, decreased the inflammation and inhibited the expression of CD54 and activation of NF-κB p65. CONCLUSION: The increase in the expression of CD54 and the activation of NF-κB p65 in the lung tissues of ALI were involved in the formation of ALI. Propolis ameliorated the lung damage, which maybe related to the inhibition of CD54 expression and NF-κB p65 activation. |
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| Keywords: | Propolis Repiratory distress syndrome adult Intercellular adhesion molecule-1 CD54 NF-kappa B |
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