Influence of glycine on LBP mRNA expression induced by LPS in the liver of rats |
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| Authors: | SHAN Yu LU Da-xiang WANG Hua-dong QI Ren-bin FU Yong-mei LI Xiao-juan LI Chu-jie |
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| Institution: | Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | AIM:To study the influence of glycine(GLY) on lipopolysaccharide-binding protein(LBP) mRNA expression induced by LPS.METHODS:The level of LBP mRNA expression in liver tissues of rats was examined by RT-PCR, and the effects of glycine on LBP mRNA expression in liver tissues of rats induced by LPS were investigated.RESULTS: The level of LBP mRNA expression in hepatic tissue of rats in the LPS group was significantly higher than that in the control group(P＜0.01), the level of LBP mRNA expression in the hepatic tissue of rats in the LPS+GLY group was lower than that in the LPS group(P＜0.01).CONCLUSION:LPS can induce LBP mRNA expression in the hepatic tissue of rats, glycine can inhibit LBP mRNA expression in the hepatic tissue of rats treated by LPS. |
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| Keywords: | Glycine Lipopolysaccharides Lipopolysaccharide binding protein |
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