| 血红铆钉菇多糖对小鼠S_（180）肉瘤的抑制作用 |
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| 引用本文： | 唐超,王清吉,葛蔚,王金叶.血红铆钉菇多糖对小鼠S_（180）肉瘤的抑制作用[J].安徽农业科学,2010,38(6):2966-2967. |
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| 作者姓名： | 唐超 王清吉 葛蔚 王金叶 |
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| 作者单位： | 青岛农业大学,山东青岛,266109 |
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| 摘 要： | 目的]研究血红铆钉菇多糖对小鼠S180肉瘤的抑制作用及免疫增强作用,以找到一种副作用小的抑制肿瘤新方法。方法]以低、中、高不同剂量血红铆钉菇多糖及环磷酰胺20 mg/（kg.d）]灌服小鼠,观察抑瘤效果。结果]与空白组对照,低、中、高剂量血红铆钉菇多糖对小鼠S180肉瘤的抑制率分别为76.018%、24.216%、54.763%,低剂量组抑瘤率远高于环磷酰胺对照组（53.839%）;低剂量组小鼠的脾指数与环磷酰胺对照组相比差异显著（P〈0.05）;低剂量和中剂量组小鼠的胸腺指数与环磷酰胺对照组相比差异极显著（P〈0.01）,具有较明显地保护免疫器官的作用。结论]低剂量血红铆钉菇多糖可以有效抑制小鼠S180肉瘤,具有较强的抑瘤活性,同时能够有效保护免疫器官。
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| 关 键 词： | 血红铆钉菇 多糖 S180肉瘤 抑制 |
Inhibitory Effects of Gomphidius viscidus Polysaccharide on the Sarcoma S_(180) of Mice |
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| TANG Chao et al.Inhibitory Effects of Gomphidius viscidus Polysaccharide on the Sarcoma S_(180) of Mice[J].Journal of Anhui Agricultural Sciences,2010,38(6):2966-2967. |
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| Authors: | TANG Chao |
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| Institution: | Qingdao Agricultural University;Qingdao;Shandong 266109 |
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| Abstract: | Objective] The research aimed to study the inhibitory effects of Gomphidius viscidus polysaccharide on the sarcoma S180 of mice,so as to find a new method of inhibiting tumour with less side effects.Method] The mice were fed separately with the low,middle,high dosage of Gomphidius viscidus polysaccharide and 20 mg/(kg·d)cylophosphamide.And the inhibitory effects were observed.Result] Compared with control group,the inhibitory rate of the low,middle,high dosage of Gomphidius viscidus polysaccharide on sarcoma S180 was 76.018%,24.22%,54.763%,respectively.The inhibitory rate of the low dosage group was higher than that of cylophosphamide control group(53.839%).There was significant difference on the index of spleen between the low dosage group and the cylophosphamide group(P<0.05).There was extremely significant difference on the index of thymus between the low,middle dosage group and cylophosphamide group(P<0.01).Gomphidius viscidus polysaccharide had more obvious protection on the immune organs.Conclusion] The low dosage of Gomphidius viscidus polysaccharide can inhibit the sarcoma S180 of mice effectively,with stronger antitumor activity.At the same time,it can protect the immunity organs. |
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| Keywords: | Gomphidius viscidus Polysaccharide Sarcoma S180 Inhibition |
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