| 恩诺沙星与硫酸丁胺卡那霉素对奶牛乳房炎常见病原菌的联合药敏试验 |
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| 引用本文： | 王爽,;张鹏宇,;刘宇,;王岩,;李丹,;朱丹丹,;和翀翼,;史同瑞.恩诺沙星与硫酸丁胺卡那霉素对奶牛乳房炎常见病原菌的联合药敏试验[J].中国奶牛,2014(8):29-31. |
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| 作者姓名： | 王爽 ;张鹏宇 ;刘宇 ;王岩 ;李丹 ;朱丹丹 ;和翀翼 ;史同瑞 |
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| 作者单位： | [1]黑龙江省兽医科学研究所,齐齐哈尔161003; [2]天津艾森生物工程有限公司,天津301609 |
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| 摘 要： | 本试验对恩诺沙星和硫酸丁胺卡那霉素在4种奶牛乳房炎常见病原菌（无乳链球菌、化脓链球菌、金黄色葡萄球菌、致病性大肠埃希氏菌）联合药敏试验中的相互作用进行了研究。结果表明，恩诺沙星和硫酸丁胺卡那霉素对各菌的MIC为8～64μg／mL，二者联合后的FIC指数范围为0．5～1，二者联合用药时为协同作用或相加作用。
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| 关 键 词： | 恩诺沙星 硫酸丁胺卡那霉素 奶牛乳房炎 联合药敏试验 |
Susceptibility Testing of the Combination of enrofloxacin and kanamycin against Some Pathogenic Bacteria of Dairy Cow Mastitis |
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| Institution: | WANG Shuang, ZHANG Peng-yu, LIU Yu, WANG Yan, LI Dan, ZHU Dan-dan, HE Chong-yi, SHI Tong-rui (1. Heilongjiang Institute of Veterinary Science, Qiqihar 161003; 2. Tianjin Asian Bioengineering Co.,Ltd, Tianjin 301609) |
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| Abstract: | To study the interaction between enrofloxacin and kanamycin against the bacteria of dairy cow mastitis, the susceptibility testing of drug combination to Streptococcus agalactiae, Streptococcus pyogenes, Staphylococcus aureus and E.coli in vitro was conducted. The minimal inhibitory concentration（MIC） of enrofloxacin and kanamycin against the batertia was determined with the grade dilution method. The fractional inhibitory concentration（FIC） was measured with checkerboard microdilution method. The results showed MIC of enrofloxacin and kanamycin against the batertia was 8-64μg/mL and the FIC of enrofloxacin and kanamycin was 0.5-1. The study suggested that the combination of enrofloxacin and kanamycin to Streptococcus agalactiae, Streptococcus pyogenes and E.coli had additive effect, and to Staphylococcus aureus demonstrated synergic action. |
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| Keywords: | Enrofloxacin Kanamycin Dairy cow mastitis Combination susceptibility testing |
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