Pharmacokinetics of Curcumin Solid Dispersion in Piglets |
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| Authors: | LIU Ziyao HUANG Chunmei XU Ying GUO Chunna HUANG Xianhui |
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| Institution: | College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China |
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| Abstract: | A method for the detection of curcumin in pig plasma by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established firstly and the pharmacokinetics of curcumin solid dispersion and curcumin premix in piglets were studied. Sixteen healthy piglets (Yorkshire×Changbai), seven-week aged, half male and half female, were randomly divided into two groups receiving curcumin solid dispersant and curcumin premix orally at the dose of 100 mg·kg-1, respectively. Then plasma samples were collected at different time points, and the blood concentration of curcumin was determined by HPLC-MS/MS. The WinNonlin 5.2.1 software was used to analyze and calculate the pharmacokinetic parameters. The pharmacokinetic parameters of curcumin solid dispersion and curcumin premix were as follows: the area under the curve (AUC) was (104.53±38.67) and (37.82±11.48) h·ng·mL-1, time to peak concentration (Tmax) was (3.25±0.38) and (2.31±0.37) h, peak concentration (Cmax) was (26.65±9.65) and (9.55±2.75) ng·mL-1, respectively, elimination half-life time (t1/2β) was (3.55±2.17) and (6.93±0.86) h, mean residence time (MRT) was (5.23±0.53) and (4.26±0.47) h. The statistical analysis showed significant differentce (P<0.01) between curcumin solid dispersion and premix in parameters, the Tmax of curcumin solid dispersion was delayed significantly, the Cmax was increased obviously and the AUC was improved after the piglets were given curcumin solid dispersion. Compared with curcumin premix, the relative bioavailability of curcumin solid dispersion was 280.39%. The results showed that curcumin solid dispersion could improve the dissolution and absorption of curcumin in the intestinal tract and improve the relative bioavailability of curcumin, which provided a scientific basis for the development and clinical application of curcumin solid dispersions in the future. |
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| Keywords: | curcumin solid dispersion pharmacokinetic weaning piglets |
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