| 甲醛对泥鳅的毒性研究 |
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| 引用本文： | 南平,杨炀,王君,郭变,朱秋芬,常重杰.甲醛对泥鳅的毒性研究[J].河南农业科学,2012,41(1):156-159. |
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| 作者姓名： | 南平 杨炀 王君 郭变 朱秋芬 常重杰 |
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| 作者单位： | 河南师范大学生命科学学院,河南新乡,453007 |
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| 基金项目： | 河南省杰出青年基金，国家自然科学基金，河南省动物学重点学科基金 |
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| 摘 要： | 为估测甲醛的环境毒性,以泥鳅为试验动物,设置甲醛对其急性毒性、遗传毒性和生理毒性试验,研究甲醛对泥鳅的半致死质量浓度(LD50)、红细胞DNA损伤大小及对其肝脏谷丙转氨酶(GPT)和谷草转氨酶(GOT)活性的影响。结果表明,甲醛对泥鳅具有明显的毒性,其96h的LD50为365.04mg/L,安全质量浓度为176.82mg/L;试验各组的微核率均高于对照组,其最高微核率出现在最高剂量组(137.28mg/L)染毒后第6天(5.801‰),微核率与甲醛质量浓度和染毒时间呈正相关;同时酶活力与甲醛质量浓度和染毒时间则呈负相关,其GPT和GOT最低活力分别出现在最高质量浓度组染毒后第2天(28.765U/mg)、第4天(44.975U/mg)。甲醛具有较强的环境毒性,并表现出明显的时间、剂量效应。
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| 关 键 词： | 泥鳅 甲醛 环境毒性 微核 谷丙转氨酶 谷草转氨酶 |
Study on the Toxicity of Formaldehyde to Loach Misgurnus anguillicaudatus |
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| NAN Ping
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YANG Yang
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WANG Jun
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GUO Bian
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ZHU Qiu-fen
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CHANG Zhong-jie.Study on the Toxicity of Formaldehyde to Loach Misgurnus anguillicaudatus[J].Journal of Henan Agricultural Sciences,2012,41(1):156-159. |
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| Authors: | NAN Ping YANG Yang WANG Jun GUO Bian ZHU Qiu-fen CHANG Zhong-jie |
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| Institution: | *(College of Life Sciences,Henan Normal University,Xinxiang 453007,China) |
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| Abstract: | In order to evaluate the environmental toxicity of Formaldehyde,the acute toxicity,genetic toxicity and physiology toxicity of formaldehyde on loach were investigated.The results of acute toxicity showed that formaldehyde had obvious toxicity to loach and its LC50 of 96 h and safety concentration was 365.04 mg/L and 176.82 mg/L,respectively.The micronucleus rates of all treated loach were higher than that of the controls.The highest rate of micronucleus was 5.801‰ and it lied in the highest concentration test fish that was exposure 6 days.The rates of loach micronucleus was positive while the activity of GPT and GOT in liver tissue was negative correlated to the test time and test dose of formaldehyde.The lowest activity of GPT and GOT were 28.765 U/mg and 44.975 U/mg,at 2 days exposure or 4 days exposure,respectively.This suggested that formaldehyde has a strong environmental toxicity and shows significant time-effect and dose-effect. |
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| Keywords: | Misgurnus anguillicaudatus formaldehyde environmental toxicity micronucleus GPT GOT |
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