| Na2CO3催化微波合成乙酰水杨酸的研究 |
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| 引用本文： | 郝红英,侯巧芝,周芳,张莎莎.Na2CO3催化微波合成乙酰水杨酸的研究[J].安徽农业科学,2013(28):11251-11252. |
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| 作者姓名： | 郝红英 侯巧芝 周芳 张莎莎 |
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| 作者单位： | 黄河科技学院医学院,河南郑州,450063;黄河科技学院医学院,河南郑州,450063;黄河科技学院医学院,河南郑州,450063;黄河科技学院医学院,河南郑州,450063 |
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| 基金项目： | 黄河科技学院校级科研项目（KYZR20139）. |
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| 摘 要： | 目的]以水杨酸和乙酸酐为原料,采用碳酸钠作催化剂微波辐射合成乙酰水杨酸。方法]采用正交试验法,考察了催化剂用量、微波功率、辐射时间对反应产率的影响。结果]优选出的较佳反应条件为:取6.3 g水杨酸和9 ml乙酸酐,催化剂碳酸钠用量0.4g,微波功率400 W,辐射时间90 s。在此条件下,乙酰水杨酸产率达83.25%。结论]采用碳酸钠微波催化合成乙酰水杨酸,反应收率较好。
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| 关 键 词： | 碳酸钠 合成 乙酰水杨酸 正交试验 |
Synthesis of Acetylsalicylic Acid under Microwave Radiation Condition by Sodium Carbonate |
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| Institution: | HAO Hong-ying et al (Medical School, Huanghe Science and Technology College, Zhengzhou, Henan 450063) |
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| Abstract: | Aeetylsalicylic acid was synthesized using salicylic acid and acetic anhydride as raw materials and sodium carbonate as the catalyst. Method] An orthogonal experimental design was used to optimize the synthetic conditions, such as reaction sodium carbonate dos- age, the microwave power and the radiation time . Result ] The best optimization process was obtained as follows：salicylic acid 6.3 g, acetic anhydride 9ml,sodium carbonate dosage 0.4 g, 400 W as the microwave power, 90 s as the radiation time. Under this optimal condition, perfect yield of 83.25%could be obtained. Conclusion]Ideal yield of aeetylsalicylic acid was obtained by using sodium carbonate as the catalyst. |
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| Keywords: | Sodium carbonate Synthesis Acetylsalicylie acid Orthogonal experiment |
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