Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation |
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| Authors: | Hae-June Lee Joong-Sun Kim Myoung-Sub Song Heung-Sik Seo Miyoung Yang Jong Choon Kim Sung-Kee Jo Taekyun Shin Changjong Moon Sung-Ho Kim |
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| Institution: | 1Korea Institute of Radiological and Medical Science, Seoul 139-240, Korea.;2College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Korea.;3Advanced Radiation Technology Institute, KAERI, Jeonbuk 580-185, Korea.;4College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea. |
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| Abstract: | This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis. |
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| Keywords: | acute radiation syndrome amifostine hippocampus memory impairment neurogenesis |
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