Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin |
| |
| Authors: | Aspholm-Hurtig Marina Dailide Giedrius Lahmann Martina Kalia Awdhesh Ilver Dag Roche Niamh Vikström Susanne Sjöström Rolf Lindén Sara Bäckström Anna Lundberg Carina Arnqvist Anna Mahdavi Jafar Nilsson Ulf J Velapatiño Billie Gilman Robert H Gerhard Markus Alarcon Teresa López-Brea Manuel Nakazawa Teruko Fox James G Correa Pelayo Dominguez-Bello Maria Gloria Perez-Perez Guillermo I Blaser Martin J Normark Staffan Carlstedt Ingemar Oscarson Stefan Teneberg Susann Berg Douglas E Borén Thomas |
| |
| Institution: | Department of Odontology, section of Oral Microbiology, Ume? University, SE-901 87 Ume?, Sweden. |
| |
| Abstract: | Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
