Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows |
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| Authors: | Sudershan Kumar Anil K Srivastava V K Dumka Naresh Kumar Rajinder K Raina |
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| Institution: | (1) Division of Animal Reproduction, Gynaecology & Obstetrics, Faculty of Veterinary Sciences & Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences & Technology of Jammu R.S.Pura Campus, Jammu, (J&K)-181102, India;(2) National Dairy Research Institute, Karnal, Haryana, India;(3) Department of Pharmacology & Toxicology, GADVASU, Ludhiana, India;(4) Dairy Microbiology Division, National Dairy Research Institute, Karnal, India;(5) Division of Veterinary Pharmacology and Toxicology, R. S. Pura, Jammu, 181102 (J&K), India |
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| Abstract: | Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous
administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition
followed three-compartment open model. The values of Vdarea, AUC, t1/2β, ClB, MRT and P/C ratio were 0.50 ± 0.19 L.kg−1, 62.2 ± 23.3 μg.ml−1.h, 1.02 ± 0.07 h, 0.30 ± 0.09 L.kg−1.h−1, 1.55 ± 0.25 h and 0.52 ± 0.27, respectively, in healthy and 1.55 ± 0.52 L.kg−1, 37.0 ± 17.1 μg.ml−1.h, 1.56 ± 0.25 h, 0.56 ± 0.14 L.kg−1.h−1, 2.14 ± 0.34 h and 1.44 ± 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration.
For MIC90 of 0.5 μg.ml−1 the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg−1 repeated at 6 h intervals for the treatment of endometritis in cows. |
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