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| 心脉隆注射液对动脉粥样硬化大鼠血管内皮细胞的保护作用 | |
| 引用本文： | 张文静,王琳琳,宋树英.心脉隆注射液对动脉粥样硬化大鼠血管内皮细胞的保护作用[J].河北北方学院学报(自然科学版),2012,28(2):79-81. |
| 作者姓名： | 张文静 王琳琳 宋树英 |
| 作者单位： | 1. 河北北方学院基础医学院组胚教研室,河北张家口,075000 2. 河北北方学院附属第一医院肾内科,河北张家口,075000 3. 河北北方学院附属第二医院,河北宣化,075100 |
| 摘 要： | 目的探讨心脉隆注射液对动脉粥样硬化（AS）大鼠血管内皮细胞的保护作用.方法采用高脂饲料加维生素D3喂养8周的方法建立动脉粥样硬化大鼠的模型.将大鼠随机分为正常组、模型组、辛伐他汀组、心脉隆治疗组四组,高脂饲料喂养8周后取血测一氧化氮（NO）、内皮素（ET）、前列环素（PGI2）和血栓素（TXA2）的含量.结果心脉隆注射液给药8周后能明显的升高AS大鼠血清NO和血浆PGI2水平（P〈0.05）,显著降低血浆ET的含量（P〈0.05）.结论心脉隆注射液能保护AS大鼠血管内皮细胞,减轻动脉粥样硬化的进程,对动脉粥样硬化有治疗作用. |
| 关 键 词： | 心脉隆注射液 动脉粥样硬化 内皮细胞 大鼠 |
Protective Effect of Xinmailong Injecta on Vascular Endothelial Cells of Atherosclerosis Rats |
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| ZHANG Wen-jing,WANG Lin-lin,SONG Shu-ying.Protective Effect of Xinmailong Injecta on Vascular Endothelial Cells of Atherosclerosis Rats[J].Journa of Hebei North University:Natural Science Edition,2012,28(2):79-81. | |
| Authors: | ZHANG Wen-jing WANG Lin-lin SONG Shu-ying |
| Institution: | 1.Basic Medical College,Hebei North University,Zhangjiakou 075000,Hebei,China; 2.The First Affiliated Hospital,Hebei North University,Zhangjiakou 075000,Hebei,China; 3.The Second Affiliated Hospital,Hebei North University,Xuanhua 075100,Hebei,China) |
| Abstract: | Objective To study the protective effect of Xinmailong(XML) injecta on vascular endothelial cells of the atherosclerosis Rats.Methods AS model of rat was made by feeding high grease food and Vitamin D3,and randomly divided into 4 groups including normal group,model group,simvastatin group and XML injecta group.The contents of NO,ET,PGI2,TXA2 were tested after the rat model of Atherosclerosis was established by feeding high lipid diet for 8 weeks.Results Compared with that of normal group the levels of NO,PGI2 in the XML injecta group increased significantly and the levels of ET decreased notably(P<0.05).Conclusion XML injecta had the effects of protecting vascular endothelial cells of the atherosclerosis rats and could inhibit the formation and development of atherosclerosis. |
| Keywords: | Xinmailong injecta atherosclerosis vascular endothelial cells rat |
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