Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein |
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| Authors: | Lezcano N Mrzljak L Eubanks S Levenson R Goldman-Rakic P Bergson C |
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| Institution: | Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA. |
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| Abstract: | The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex. |
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