| 肝脏极低密度脂蛋白合成和分泌的研究进展 |
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| 引用本文： | 闻治国,侯水生,谢明,黄苇.肝脏极低密度脂蛋白合成和分泌的研究进展[J].动物营养学报,2011(11):1854-1861. |
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| 作者姓名： | 闻治国 侯水生 谢明 黄苇 |
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| 作者单位： | 中国农业科学院北京畜牧兽医研究所动物营养学国家重点实验室; |
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| 基金项目： | 现代水禽产业技术体系建设专项资金资助(ny-cytx-45) |
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| 摘 要： | 肝脏中极低密度脂蛋白(very low-density lipoprotein,VLDL)的过量沉积是引起脂质代谢紊乱进而形成脂肪肝的主要原因.本文综述了VLDL组装过程的最新特点以及肝脏中VLDL合成和分泌的影响因素,包括与VLDL合成相关的载脂蛋白B- 100( apoB-100)的结构和功能、微粒体甘油三酯转运蛋...
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| 关 键 词： | 肝脏 极低密度脂蛋白 合成 分泌 影响因素 |
Synthesis and Secretion of Hepatic Very Low-Density Lipoprotein:a Review |
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| WEN Zhiguo HOU Shuisheng XIE Ming HUANG Wei.Synthesis and Secretion of Hepatic Very Low-Density Lipoprotein:a Review[J].Acta Zoonutrimenta Sinica,2011(11):1854-1861. |
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| Authors: | WEN Zhiguo HOU Shuisheng XIE Ming HUANG Wei |
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| Institution: | WEN Zhiguo HOU Shuisheng XIE Ming HUANG Wei(State Key Laboratory of Animal Nutrition,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China) |
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| Abstract: | Excess deposition of very low-density lipoproteins(VLDL) leading to lipid metabolic disorders is the major cause of fatty liver.This review provides the latest understanding in aspects of VLDL assembly process and factors affecting hepatic VLDL synthesis and secretion,including structure-function relationships within apolipoprotein B-100(apoB-100),role of microsomal triglyceride transfer protein(MTP) in modulating VLDL synthesis,and other hepatic proteins and fatty acids contributing to VLDL assembly.In add... |
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| Keywords: | liver VLDL synthesis secretion influence factor |
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