| 狂犬病病毒致神经功能异常机制的研究进展 |
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| 引用本文： | 单晶辉,关振宏,段铭,张茂林.狂犬病病毒致神经功能异常机制的研究进展[J].动物医学进展,2011(8):66-69. |
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| 作者姓名： | 单晶辉 关振宏 段铭 张茂林 |
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| 作者单位： | 人兽共患病研究教育部重点实验室吉林大学人兽共患病研究所;吉林大学畜牧兽医学院; |
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| 基金项目： | 国家自然科学基金项目(31072147); 吉林省科技发展计划重点项目(2010095420080930); 国家科技支撑(2008BAB96B11-3) |
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| 摘 要： | 狂犬病是一种以神经系统感染为特征的高度致死性人兽共患病毒性传染病,危害大,但其致病机制尚不明确.狂犬病病毒(RV)G蛋白与神经细胞表面受体发生特异性结合决定其嗜神经特性,其他RV结构蛋白对RV感染具有保护和调节作用；机体感染RV后神经元结构和机体内与功能相关的部分蛋白及基因表达水平发生改变,而且RV在神经核的分布可能影...
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| 关 键 词： | 狂犬病病毒 神经功能异常 致病机制 |
Progress on the Pathogenesis of Neuronal Dysfunction Due to Rabies Virus Infection |
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| SHAN Jing-hui,GUAN Zhen-hong,DUAN Ming,ZHANG Mao-lin.Progress on the Pathogenesis of Neuronal Dysfunction Due to Rabies Virus Infection[J].Progress In Veterinary Medicine,2011(8):66-69. |
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| Authors: | SHAN Jing-hui GUAN Zhen-hong DUAN Ming ZHANG Mao-lin |
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| Institution: | SHAN Jing-hui,GUAN Zhen-hong,DUAN Ming,ZHANG Mao-lin (Key laboratory of Zoonosis,Ministry of Education,Institute of Zoonosis,College of Animal Science and Veterinary Medicine,Jilin University,Changchun,Jilin130062,China) |
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| Abstract: | Rabies is a highly contagious lethal zoonosis caused by rabies virus,which is characterized as the neurotropic infection.Many works had focused on it,however,its pathogenesis remains unclear.G protein of rabies virus(Rabies Virus,RV) interacting with nerve cell surface receptors to determine their neurotropic specific binding characteristics,other structural proteins of RV play an important role in protecting and regulating of RV,RV could significantly change the neuronal structures and the expression level... |
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| Keywords: | Rabies virus neurological dysfunction pathogenesis |
| 本文献已被 CNKI 等数据库收录！ |
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