Assistance of microbial glycolipid antigen processing by CD1e |
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| Authors: | de la Salle Henri Mariotti Sabrina Angenieux Catherine Gilleron Martine Garcia-Alles Luis-Fernando Malm Dag Berg Thomas Paoletti Samantha Maître Blandine Mourey Lionel Salamero Jean Cazenave Jean Pierre Hanau Daniel Mori Lucia Puzo Germain De Libero Gennaro |
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| Institution: | INSERM, U725, Etablissement Francais du Sang-Alsace, F-67065 Strasbourg, France. |
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| Abstract: | Complexes between CD1 molecules and self or microbial glycolipids represent important immunogenic ligands for specific subsets of T cells. However, the function of one of the CD1 family members, CD1e, has yet to be determined. Here, we show that the mycobacterial antigens hexamannosylated phosphatidyl-myo-inositols (PIM6) stimulate CD1b-restricted T cells only after partial digestion of the oligomannose moiety by lysosomal alpha-mannosidase and that soluble CD1e is required for this processing. Furthermore, recombinant CD1e was able to bind glycolipids and assist in the digestion of PIM6. We propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune responses. |
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