| 氟苯尼考与黏菌素联用对猪大肠杆菌与链球菌的体外抗菌作用 |
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| 引用本文： | 康宇,律海峡,胡功政,刘建华,潘玉善.氟苯尼考与黏菌素联用对猪大肠杆菌与链球菌的体外抗菌作用[J].河南农业科学,2008(9). |
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| 作者姓名： | 康宇 律海峡 胡功政 刘建华 潘玉善 |
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| 作者单位： | 河南农业大学,牧医工程学院,河南,郑州,450002 |
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| 基金项目： | 河南省农业科技成果转化项目 |
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| 摘 要： | 采用棋盘法,测定了氟苯尼考与黏菌素联用对猪大肠杆菌、链球菌分离株的体外抗菌活性。结果表明:猪大肠杆菌、链球菌分离株均对氟苯尼考呈现出耐药性,其最小抑菌浓度(MIC)为0.64~5.12 mg/L,大部分大肠杆菌分离株对黏菌素耐药,仅对其中一株有明显效果。棋盘法测得氟苯尼考与黏菌素联合对猪大肠杆菌、猪链球菌分离株的部分抑菌浓度(FIC)指数为0.031 26~0.140 63,均为协同作用。当浓度大于或等于0.16 mg/L时即呈现出协同作用。
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| 关 键 词： | 氟苯尼考 黏菌素 联合用药 抗菌活性 猪大肠杆菌 猪链球菌 |
In vitro Antibacterial Activity of the Combination of Florfenicol and Colistin Sulfate on Escherichia coli and Streptococcus Isolated from Pigs |
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| KANG Yu,L Hai-xia,HU Gong-zheng,LIU Jian-hua,PAN Yu-shan.In vitro Antibacterial Activity of the Combination of Florfenicol and Colistin Sulfate on Escherichia coli and Streptococcus Isolated from Pigs[J].Journal of Henan Agricultural Sciences,2008(9). |
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| Authors: | KANG Yu L Hai-xia HU Gong-zheng LIU Jian-hua PAN Yu-shan |
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| Institution: | KANG Yu,L(U) Hai-xia,HU Gong-zheng,LIU Jian-hua,PAN Yu-shan |
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| Abstract: | The in vitro antibacterial activities of florfenicol and colistin sulfate against the Escherichia coli and Streptococcus isolates derived from pigs were investigated by checkerboard method in this paper.The results showed that both of the E.coli and Streptococcus isolates were tolerant to florfenicol and the minimum inhibitory concentrations(MIC) were 0.64-5.12 mg/L.Most of the E.coli isolates were resistant to colistin sulfate except one case.When used combined,the fractional inhibitory concentrations(FIC) of florfenicol and colistin sulfate varied from 0.031 26 to 0.140 63,and represented the synergistic effects when the concentration exceed or equal to 0.16 mg/L. |
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| Keywords: | Florfenicol Colistin Synergistic effect Antibacterial activity Escherichia coli Streptococcus |
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