| 副黏病毒V蛋白抗干扰素作用的研究进展 |
| |
| 引用本文： | 邓书,杨发龙,岳华,孟宇航.副黏病毒V蛋白抗干扰素作用的研究进展[J].动物医学进展,2008,29(4):56-59. |
| |
| 作者姓名： | 邓书 杨发龙 岳华 孟宇航 |
| |
| 作者单位： | 西南民族大学生命科学与技术学院,四川成都,610041 |
| |
| 摘 要： | 副黏病毒的V蛋白是结构蛋白P基因内使用不同的阅读框编码产生的一种非结构蛋白,具有抗干扰素(IFN)的作用。副黏病毒科不同成员间V蛋白的产生机制不同,国内外利用反向遗传、RNA干扰等技术缺失或抑制V蛋白,通过检测IFN产生及作用通路上关键蛋白的变化情况研究其抗IFN作用机制,发现副黏病毒V蛋白既可直接阻止IFN产生,也可阻断IFN抗病毒JAK/STAT作用通路。文章对副黏病毒V蛋白、干扰素的产生及其抗病毒作用机制,特别是V蛋白抗IFN作用的研究进展及应用前景做一综述。
|
| 关 键 词： | 副黏病毒 V蛋白 干扰素 |
| 文章编号： | 1007-5038(2008)04-0056-04 |
| 修稿时间： | 2008年1月14日 |
Advance in Paramyxovirus V Proteins and Their Interferon Resistance Effects |
| |
| DENG Shu,YANG Fa-long,YUE Hua,MENG Yu-hang.Advance in Paramyxovirus V Proteins and Their Interferon Resistance Effects[J].Progress In Veterinary Medicine,2008,29(4):56-59. |
| |
| Authors: | DENG Shu YANG Fa-long YUE Hua MENG Yu-hang |
| |
| Abstract: | V proteins are non-structural proteins of paramyxovirus that are generated due to the use of different open reading frame within P gene and are responsible for interferon(IFN)resistance.V protein is produced in a varity of forms in different paramyxovirus families.The IFN resistance effect of the V proteins have been extensively investigated by using reverse genetics systems,RNA interfere methods and detecting the crucial proteins related to IFN synthesis and signal pathway of IFN inhibition.These study have revealed that V proteins can directly block the induction of IFN,the activation of IFN signaling pathways or both of them.The present paper reviewed recent researches on paramyxovirus V proteins,IFN synthesis,antiviral mechanism of IFN and,especially,IFN resistance effect of V proteins.The further application of V proteins was also prospected. |
| |
| Keywords: | Paramyxovirus V protein interferon |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
