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Effects of the herbicide LASSO MTX (alachlor 42% W/V) on biometric parameters and liver biomarkers in the common carp (Cyprinus carpio) |
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| Authors: | Premysl Mikula Jana Blahova Marcela Havelkova Martin Hulak |
| Institution: | a University of Veterinary and Pharmaceutical Sciences, Faculty of Veterinary Hygiene and Ecology, Palackeho 1-3, 612 42 Brno, Czech Republic b Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 126/3, 625 00 Brno, Czech Republic c Institute of Biostatistics and Analyses, Masaryk University, Kamenice 126/3, 625 00 Brno, Czech Republic d Research Institute of Fish Culture and Hydrobiology at Vodnany, Zatisi 728/II, 389 25 Vodnany, Czech Republic |
| Abstract: | The aim of the study was to evaluate the effect of subchronic exposure to the herbicide LASSO MTX (alachlor 42% W/V) on biometric parameters and important liver biomarkers in the common carp (Cyprinus carpio). One year old fish were exposed for 28 days to LASSO MTX added to the tank water at concentrations of 240 and 2400 μg L−1. The exposure did not affect fish biometric parameters. Glutathione-S-tranferase (GST) activity in liver (hepatopancreas) remained unchanged in exposed fish when compared to controls. However, significant induction of total cytochrome P 450 (CYP 450), ethoxyresorufin-O-deethylase (EROD) activity and elevated glutathione (GSH) in liver of exposed fish were detected. |
| Keywords: | Chloroacetanilides Cytochrome P 450 Ethoxyresorufin-O-deethylase EROD Reduced glutathione GSH Glutathione-S-transferase GST Vitellogenin |
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