Asymmetric inheritance of mother versus daughter centrosome in stem cell division |
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| Authors: | Yamashita Yukiko M Mahowald Anthony P Perlin Julie R Fuller Margaret T |
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| Institution: | Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA. yukikomy@umich.edu |
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| Abstract: | Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation. |
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