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Induction of inflammatory host immune responses by organisms belonging to the genera Chlamydia/Chlamydophila |
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| Authors: | Entrican Gary Wattegedera Sean Rocchi Mara Fleming Diana C Kelly Rodney W Wathne Gwen Magdalenic Vjera Howie Sarah E M |
| Institution: | a Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, UK b Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh Chancellor’s Building, Little France Crescent, Edinburgh EH16 4SB, UK c Department of Pathology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK |
| Abstract: | Chlamydia/Chlamydophila are a family of intracellular gram-negative bacteria that infect their hosts primarily via mucosal epithelia. Chronic disease associated with bacterial persistence, inflammation and tissue damage are common sequelae of infection with these organisms. Human epithelial cell lines respond to infection by releasing pro-inflammatory cytokines and chemokines such as interleukin (IL)-6 and IL-8, and upregulating the expression of mRNA encoding Iκ-B , the endogenous inhibitor of NF-κB. However, Iκ-B is not upregulated in response to bacterial lipopolysaccharide (LPS). The failure of epithelial cells to respond to LPS is associated with the absence of surface expression of CD14. Identification of the components of Chlamydia/Chlamydophila that can induce pro-inflammatory mediators coupled with the mechanisms by which epithelial cells detect infection and respond accordingly will advance the development of preventative strategies. |
| Keywords: | Pro-inflammatory cytokines Chlamydia Epithelial cells Pattern recognition receptors |
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