Resident lymphocytes in the epidermis and adnexal epithelia of normal dorsolateral thorax of alpacas |
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| Authors: | Mitzi D Clark Jeanine Peters-Kennedy Danny W Scott |
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| Institution: | Department of Clinical Sciences (Clark, Scott) and Department of Biomedical Sciences (Peters-Kennedy), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA. |
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| Abstract: | A small population of resident T-lymphocytes is present in the normal epidermis of skin from humans, mice, sheep, and cattle. The objective of this study was to determine the prevalence of lymphocytes, CD3+ cells (T-lymphocytes) and CD79a+ cells (B-lymphocytes and plasma cells), in the epidermis and adnexal epithelia of alpacas. Skin-biopsy specimens from the normal skin of the dorsolateral thorax of 31 alpacas were examined histologically and immunohistochemically for the presence of CD3+ cells and CD79a+ cells in the epidermis and adnexal epithelia. CD3+ T-lymphocytes, but not CD79a+ cells, were present in the epidermis and adnexal epithelia. Therefore, in the absence of other signs of inflammation, the presence of lymphocytes in these structures in skin-biopsy specimens should be considered normal. |
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