| 加丽素红中角黄素在鸡体内的药代动力学研究 |
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| 引用本文： | 田洋,杨兰兰,徐昆龙,肖蓉,李栋,何梦恒,史崇颖.加丽素红中角黄素在鸡体内的药代动力学研究[J].动物营养学报,2012,24(6):1092-1097. |
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| 作者姓名： | 田洋 杨兰兰 徐昆龙 肖蓉 李栋 何梦恒 史崇颖 |
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| 作者单位： | 1. 云南农业大学食品科学技术学院,昆明,650201
2. 云南农业大学动物科学技术学院,昆明,650201 |
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| 基金项目： | 云南省自然科学基金项目(2010ZC082);云南省高端科技人才引进计划项目(2009CI125-03);省财政厅政府性公共科技服务与活动专项(A3006884) |
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| 摘 要： | 本试验旨在探讨加丽素红中角黄素在鸡体内的药代动力学特征.选取19周龄的海兰蛋鸡12只,单次灌胃口服加丽素红9.6 mg/kg BW,在72 h内不同时间段分10次采集静脉血,用高效液相色谱法测定鸡血清中角黄素的质量浓度,并利用3P97药代动力学程序软件处理血药浓度-时间数据.结果如下:加丽素红经口服给药后,角黄素在鸡体内的血药浓度-时间数据符合一级吸收一室模型,其理论方程为C=0.471(e-0.036-e-0.190),主要药代动力学参数为:吸收半衰期t1/2(Ka)=(3.643±0.205)h,消除半衰期t1/2(Ke)=(19.263±1.312)h,达峰时间Tmax=(10.795±1.007)h,达峰浓度Cmax=(0.259±0.048)μg/mL,血药浓度-时间曲线下面积AUC=(10.607±1.029)μg/(mL·h),总体清除率CLB=(0.905±0.076)L/(kg·h),表观分布容积Vd=(2.515±0.133)L/kg.上述结果表明,角黄素在鸡体内血药浓度的变化表征了加丽素红在鸡体内代谢的变化规律,具有吸收分布较迅速、达峰快、体内分布广泛、消除速度较慢等特点.
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| 关 键 词： | 加丽素红 角黄素 鸡 代谢动力学 |
Pharmacokinetics of Canthaxanthin in Carophyll Red in Chickens |
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| TIAN Yang
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YANG Lanlan
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XU Kunlong
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XIAO Rong
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LI Dong
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HE Mengheng
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SHI Chongying.Pharmacokinetics of Canthaxanthin in Carophyll Red in Chickens[J].Acta Zoonutrimenta Sinica,2012,24(6):1092-1097. |
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| Authors: | TIAN Yang YANG Lanlan XU Kunlong XIAO Rong LI Dong HE Mengheng SHI Chongying |
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| Institution: | 1(1.College of Food Science and Technology,Yunnan Agricultural University,Kunming 650201,China; 2.College of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China) |
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| Abstract: | The pharmacokinetic characteristics of canthaxanthin in Carophyll Red in chickens were investigated in this study.After oral administration of Carophyll Red at a dose of 9.6 mg per kg Hy-Line laying hens(12 hens,aged 19 weeks) body weight,venous blood was collected for 10 times in different time periods within 72 h,and serum canthaxanthin concentration was determined by high performance liquid chromatography.Simultaneously,all of the serum drug concentration-time data were dealt with the 3P97 pharmacokinetic software.The results showed that after oral administration of Carophyll Red,serum drug concentration-time data of canthaxanthin in chickens were best described by a one-compartment model with first-order absorption.The theoretical equation was C=0.471(e-0.036-e-0.190),and the main pharmacokinetic parameters as follows: absorption half-life t1/2(Ka)=(3.643±0.205) h,elimination half-life t1/2(Ke)=(19.263±1.312) h,time of the maximum concentration Tmax=(10.795±1.007) h,maximum concentration Cmax=(0.259±0.048) μg/mL,area under serum concentration-time curve AUC=(10.607±1.029) μg/(mL·h),total body clearance CLB=(0.905±0.076) L/(kg·h),and apparent volume of distribution Vd=(2.515±0.133) L/kg.These results indicate that the concentration change of canthaxanthin in serum can reflect the metabolic regularity of Carophyll Red in chickens.Canthaxanthin is absorbed rapidly,and reaches the peak concentration fast,distributes in tissues and organs widely and eliminates slowly in chickens. |
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| Keywords: | Carophyll Red canthaxanthin chicken pharmacokinetics |
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