| 动物食欲调节的中枢信号通路 |
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| 引用本文： | 刘 磊,宋志刚.动物食欲调节的中枢信号通路[J].动物营养学报,2012(2):226-231. |
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| 作者姓名： | 刘 磊 宋志刚 |
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| 作者单位： | 山东农业大学动物科技学院，泰安 ２７１０１8 |
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| 基金项目： | 国家自然科学基金（３１０７２０４５）；公益性行业（农业）科研专项（２０１００３０１１） |
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| 摘 要： | 下丘脑是动物食欲调节的中枢，外周食欲信号在下丘脑中经食欲调节网络整合，产生饱感或饥饿。其中，以 ５′－磷酸腺苷激活的蛋白激酶（ＡＭＰＫ）调控位点上的 ＡＭＰＫ-ＡＣＣ-ＣＰＴ１和 ＵＣＰ２-ＦＯＸＯ１-ｐＣＲＥＢ信号通路以及雷帕霉素靶蛋白（ｍＴＯＲ）调控位点上的 ＰＩ３Ｋ-Ａｋｔ-ｍＴＯＲ和 ｍＴＯＲ-４ＥＢＰ１／ｐ７０Ｓ６Ｋ-ＮＰＹ／ＡｇＲＰ信号通路尤为重要。ＡＭＰＫ和 ｍＴＯＲ在 ＡＭＰＫ-ＴＳＣ ｍＴＯＲ通路、固醇类调节因子绑定蛋白（ＳＲＥＢＰ）基因表达和吞噬启动激酶（Ｕｌｋ１）活性通路上存在互作。外周营养和能量信号传输到下丘脑后，经过这些网络的传输和分析，作用于下丘脑中的食欲相关肽，最终调控动物的采食行为。
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| 关 键 词： | 下丘脑 食欲 调节通路 |
Central Appetite-Regulating Signaling Pathways in Animals |
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| LIU Lei,SONG Zhigang.Central Appetite-Regulating Signaling Pathways in Animals[J].Acta Zoonutrimenta Sinica,2012(2):226-231. |
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| Authors: | LIU Lei SONG Zhigang |
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| Institution: | *(College of Animal Science and Technology,Shandong Agricultural University,Tai’an 271018,China) |
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| Abstract: | Hypothalamus is the center of appetite regulation in animals,which integrates the peripheral and central signals to generate satiety or hunger.5′-AMP-activated protein kinase(AMPK) and mammalian target of rapamycin(mTOR) are the signals found recently in the network of food or feed intake regulation in the hypothalamus.The pathways of AMPK-ACC-CPT1,UCP2-FOXO1-pCREB,PI3K-Akt-mTOR and mTOR-4EBP1/p70S6K-NPY/AgRP are the most important ones.AMPK and mTOR might cross talk in the way of AMPK-TSC-mTOR,the gene expression of sterol regulatory element-binding proteins(SREBP) and the activity of UNC-51-like kinase(Ulk1).These signaling pathways respond to the signal transmission of nutrients and hormones to the hypothalamus,and regulate the expression of the anorexic or orexigenic peptides,and finally regulate the animal appetite. |
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| Keywords: | hypothalamus appetite signaling pathways |
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