| 应激性抑郁症大鼠眶额叶Fos蛋白表达的变化 |
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| 引用本文： | 安锋利,安书成.应激性抑郁症大鼠眶额叶Fos蛋白表达的变化[J].动物医学进展,2010,31(10). |
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| 作者姓名： | 安锋利 安书成 |
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| 作者单位： | 1. 渭南师范学院环境与生命科学系,陕西渭南,714000;兰州大学生命科学学院,甘肃兰州,730000
2. 陕西师范大学生命科学学院,陕西西安,710062 |
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| 基金项目： | 渭南师范学院科研基金 |
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| 摘 要： | 大脑眶额叶(OFC)是与情绪密切相关的脑区,试验主要通过强迫游泳制造应激抑郁大鼠模型,免疫组织化学方法观察模型鼠大脑OFC及其他脑区Fos蛋白表达变化,以揭示OFC区与应激性抑郁症之间的关系。结果与对照组比较,强迫游泳应激后大鼠眶额叶、海马、丘脑室旁核、杏仁内侧核等多个脑区均有Fos蛋白高表达,差异极显著(P0.01)。强迫游泳应激后OFC区Fos蛋白高表达,结果表明,OFC区参与了应激性抑郁症的发生。
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| 关 键 词： | 眶额叶 应激性抑郁 免疫组织化学 强迫游泳 大鼠 |
Variation of FOs Expresion in Orbitofrontal Cortex of Stress-induced Depression in Rat |
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| AN Feng-li,AN Shu-cheng.Variation of FOs Expresion in Orbitofrontal Cortex of Stress-induced Depression in Rat[J].Progress In Veterinary Medicine,2010,31(10). |
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| Authors: | AN Feng-li AN Shu-cheng |
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| Institution: | AN Feng-li1,2,AN Shu-cheng3 (1.Department of Environment and Life Science,Weinan Teachers University,Weinan,Shaanxi,714000,China,2.School of Life Science,Lanzhou University,Lanzhou,Gansu,730000,3.College of Life Science,Shaanxi Normal University,Xi'an,710062,China) |
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| Abstract: | Orbitofrontal cortex is closely related to brain emotion.The research produced depression rat model through swimming mainly forced and observed Fos expression in OFC and other brain areas by immunohistochemistry method.It primarily aimed to reveal the function of OFC area in the pathology of stress-induced depression.The results showed that after forced swimming,the stressed rats had more positive expression of Fos in OFC,hippocampus,PVN and ME compared with control rats.The results indicated that OFC is ac... |
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| Keywords: | orbitofrontal cortex stress depression immunohistochemistry forced swimming rat |
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