| 饲粮添加叶酸对PCV-2攻击下断奶仔猪体重和组织病变的影响 |
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| 引用本文： | 高庆,张克英,陈代文,徐志文,彭西.饲粮添加叶酸对PCV-2攻击下断奶仔猪体重和组织病变的影响[J].中国畜牧杂志,2012,38(3):29-34. |
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| 作者姓名： | 高庆 张克英 陈代文 徐志文 彭西 |
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| 作者单位： | 1. 四川农业大学动物营养研究所,教育部动物抗病营养重点实验室,四川雅安625014
2. 四川农业大学动物生物技术中心,四川雅安,625014 |
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| 基金项目： | 教育部长江学者和创新团队发展计划 |
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| 摘 要： | 试验旨在探明饲粮添加不同水平叶酸(FA)对圆环病毒-2(PCV-2)攻击下断奶仔猪增重和组织病变的影响。选用45头PCV-2阴性、初重8.44kg的健康去势、28d断奶DLY仔猪,饲喂添加不同水平FA(0、0.3、15mg/kg)的饲粮7 d后,进行PCV-2攻毒,继续饲喂相应饲粮28 d。第1、7(攻毒前)、21天和第35天采集组织样品;测定体重、腹泻指数、组织病变、血清PCV-2特异抗体、猪瘟抗体和细胞因子水平。结果表明:无PCV-2攻击,断奶应激导致仔猪免疫组织损伤,饲粮添加15 mg/kg FA可明显改善淋巴组织病变;PCV-2攻击导致免疫抑制与组织损伤,仔猪体重极显著降低(P<0.01);饲粮不添加FA仔猪免疫抑制和组织病变最严重,添加0.3 mg/kg FA缓解了免疫抑制而组织病变减轻,添加15 mg/kg FA则不利于组织修复。
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| 关 键 词： | 叶酸 圆环病毒-2 组织病变 免疫抑制 断奶仔猪 |
Effects of Dietary Supplementation with Folic Acid on Body Weight and Histopathological Changes of Weanling Piglets with Porcine Circovirus-2 Challenging |
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| GAO Qing
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ZHANG Ke-ying
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CHEN Dai-wen
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XU Zhi-wen
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PENG Xi.Effects of Dietary Supplementation with Folic Acid on Body Weight and Histopathological Changes of Weanling Piglets with Porcine Circovirus-2 Challenging[J].Chinese Journal of Animal Science,2012,38(3):29-34. |
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| Authors: | GAO Qing ZHANG Ke-ying CHEN Dai-wen XU Zhi-wen PENG Xi |
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| Institution: | 1(1.Institute of Animal Nutrition,Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education,Sichuan Agricultural University,Sichuan Ya′an 625014,China; 2.Animal Biotechnology Centre,Sichuan Agricultural University,Sichuan Ya′an 625014,China) |
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| Abstract: | To detect the effects of dietary supplementation with folic acid(FA) on body weight and histopathological changes of weanling piglets with PCV-2 challenging,a 2×3 factorial(two states: PCV-2 challenge or not;three added FA levels: 0,0.3,or 15 mg/kg) randomized block design was conducted in this study.Fourty-five PCV-2 negative,8.44 ± 0.12 kg,crossbred(Duroc × Landrace × Yorkshire) castrated piglets were weaned at(28 ± 1) days of age,and fed ad libitum with three diets for 35 days,respectively.Seven piglets from each diet group were challenged with PCV-2 in the morning of d7.Blood and tissue samples were collected on d1,d7(without PCV-2 challenge),d21 & d35.The bodyweight,diarrhea incidence,histopathological change,and serum levels of cytokines were measured,respectively.Results showed that immune tissue damages were induced by intense stress during weaning in piglets without PCV-2 infection;Dietary supplementation with FA 15 mg/kg obviously restored the tissue damage.After 14 days since PCV-2 challenge,the piglets had the depressed body weight(P<0.01) with the intensified immunosuppression and tissue damage;Compared with the basal diet,the Diet supplementation with FA 0.3 mg/kg relieved partly the immunosuppression and tissue damages;but the diet supplementation with 15 mg/kg FA disadvantaged restoration of immune system in piglets.It implied that the suitable level of dietary FA might be different for piglets with different PCV-2infection status. |
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| Keywords: | folic acid porcine circovirus-2 weanling piglet histopathological changes immunosuppression |
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