| 抗白色念球菌的复方"克清甲"软膏毒性研究 |
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| 引用本文： | 魏琴,雷春娟,殷中琼,周黎军,杜永华,周锦霞.抗白色念球菌的复方"克清甲"软膏毒性研究[J].安徽农业科学,2010,38(33):18787-18789. |
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| 作者姓名： | 魏琴 雷春娟 殷中琼 周黎军 杜永华 周锦霞 |
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| 作者单位： | 宜宾学院发酵资源与应用四川省高校重点实验室,四川宜宾,644000;四川农业大学动物医学院,四川雅安,625014;宜宾学院发酵资源与应用四川省高校重点实验室,四川宜宾,644000;宜宾学院生命科学与食品工程学院,四川宜宾,644000 |
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| 摘 要： | 目的]考察抗白色念球菌的复方＂克清甲＂软膏经皮给药及入眼对试验动物的安全性。方法]采用健康家兔进行皮肤急性毒性试验、皮肤及眼刺激试验,用健康豚鼠进行主动皮肤过敏试验,并观察。结果]复方＂克清甲＂软膏未产生急性毒性反应和眼刺激反应;对于家兔完整皮肤,单次和多次经皮给药均无刺激性,对破损皮肤有轻度刺激反应,但除去药物后这种刺激性消失;对健康豚鼠完整及破损皮肤均无致敏性。结论]复方＂克清甲＂软膏是一种安全的外用制剂。
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| 关 键 词： | 复方"克清甲"软膏 急性毒性 刺激性 过敏性 |
Toxic Study on Compound "Keqingjia" Cream with Anti-Candida albicans |
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| Institution: | WEI Qin et al (Key Laboratory of Fermentation Resources and Application of Institutes of Higher Learning in Sichuan, Yibin University, Yibin, Sichuan 644000 ) |
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| Abstract: | Objective] The research aimed to investigate the safety of compound "Keqingjia" cream(CKC)with anti-Candida albicans on animals.Method] The test about acute toxic skin reactions,skin irritation and eye irritation were experimented on health rabbits.The skin allergy test was experimented on health guinea pigs.Result] Neither acute toxic effects nor eye irritant in experimental animals were induced by applications of CKC.No irritant dermal reaction were observed in intact skin,while slight irritation reactions were observed in injured skin after the repeated applications of CKC,which faded away while removing medicine afterwards.No allergic reactions were observed in intact and injured skin of guinea pigs.Conclusion] CKC is a safe topical preparation. |
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| Keywords: | Compound "Keqingjia" cream Acute toxicity Irritation Allergy |
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