Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs |
| |
| Authors: | Nosá?ová Gabriela Prisen?ňáková Lubica Ko??álová Zuzana Ebringerová Anna Hromádková Zdenka |
| |
| Institution: | a Department of Pharmacology, Center of Experimental and Clinical Respirology, Jessenius Faculty of Medicine, Comenius University, Sklabinská 26,037 53 Martin, Slovakiab Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia |
| |
| Abstract: | Several water-soluble pectic polysaccharides were isolated from the pumpkin fruit biomass and characterized by composition, structural features and molecular properties. The pectic polysaccharides were tested for antitussive activity by studying the effects of citric acid-induced cough reflex in guinea pigs and reactivity of the airway smooth muscle in vivo conditions in comparison to the narcotic drug codeine. Oral administration of all pectic polysaccharides from pumpkin inhibited the number of coughs induced by citric acid in guinea pigs, but to various extents. The results indicated that the antitussive activity of the pectic polysaccharides is affected by their molecular and structural properties, whereby a synergistic action between the polysaccharide and non-carbohydrate components on the biological response has been suggested as well. The cough depressive efficacy of most of the tested polysaccharides was comparable and even higher than that of codeine. Moreover, the application of these polysaccharides provoked any side effects what is their advantage towards the conventional opioid-derived antitussive agents. |
| |
| Keywords: | Pumpkin (Cucurbita pepo L var Styriaca) Pectic polysaccharides Antitussive activity Cough reflex Guinea pigs Citric acid |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
