Anticholinesterase activity of standardized extract of Illicium verum Hook. f. fruits |
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| Authors: | Bhadra Santanu Mukherjee Pulok K Kumar N Satheesh Bandyopadhyay A |
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| Institution: | a School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, Indiab Indian Institute of Chemical Biology, 4 Raja SC Mallick Road, Jadavpur, Kolkata 700 032, India |
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| Abstract: | Illicium verum is a well known spice in traditional Indian system for its therapeutic potential. The present study was aimed to evaluate the acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory (BChE) activity of standardized extracts of I. verum and its oil. Present study confirmed that anethole contributed to the anticholinesterase activity of I. verum, with more specificity towards AChE. IC50 for AChE and BChE inhibitory activity of anethole was 39.89 ± 0.32 μg/mL and 75.35 ± 1.47 μg/mL, whereas for the oil, 36.00 ± 0.44 μg/mL and 70.65 ± 0.96 μg/mL respectively. Therefore I. verum can be a good lead as anti-cholinesterase agent from natural resources. |
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| Keywords: | AChE Acetylcholinesterase enzyme AD Alzheimer's disease ATCI Acetylthiocholine iodide BChE Butyrylcholinesterase BTCI Butyrylthiocholine iodide DTNB = 5 5-dithiobis 2-nitrobenzoic acid |
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