| 柠檬酸对小鼠肝脏组织氧化应激的影响 |
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| 引用本文： | 张自强,刘玉梅,邓 雯,吕琼霞.柠檬酸对小鼠肝脏组织氧化应激的影响[J].西北农业学报,2011,20(4):16-19. |
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| 作者姓名： | 张自强 刘玉梅 邓 雯 吕琼霞 |
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| 作者单位： | 河南科技大学动物科技学院,河南洛阳,471003 |
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| 基金项目： | 河南科技大学博士启动基金 |
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| 摘 要： | 为了研究柠檬酸对小鼠肝脏组织氧化应激的影响,将40只健康昆明品系小白鼠随机分为对照组(生理盐水),柠檬酸高(480 mg/kg)、中(240 mg/kg)、低(120 mg/kg)剂量组.各组小鼠每周腹腔注射相应试剂0.2 mL,连续2周,第2次注射7 d后取肝组织制作匀浆检测总超氧化物歧化酶(-SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量,同时制作石蜡切片,观察各组小鼠肝脏组织的形态变化.结果表明,与对照组相比,高剂量柠檬酸组小鼠肝脏组织T-SOD和GSH-Px活性显著降低,各剂量组MDA含量差异不显著.显微镜观察可知,柠檬酸组小鼠出现肝细胞索排列紊乱,中央静脉大量淤血,周围淋巴细胞和中性粒细胞浸润等一系列病理变化.
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| 关 键 词： | 柠檬酸 小鼠 肝脏 氧化应激 毒性 |
Effect of Citric Acid on Oxidative Stress of Liver in Mice |
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| ZHANG Ziqiang,LIU Yumei,DENG Wen,L Qiongxia.Effect of Citric Acid on Oxidative Stress of Liver in Mice[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(4):16-19. |
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| Authors: | ZHANG Ziqiang LIU Yumei DENG Wen L Qiongxia |
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| Institution: | ZHANG Ziqiang,LIU Yumei,DENG Wen,L(U) Qiongxia |
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| Abstract: | To study effect of ctric acid on oxidative stress of liver in mice,40 health Kunming mice were randomly divided into control group(0.9% saline),high dose group(480 mg/kg),middle dose group(240 mg/kg) and low dose group(120 mg/kg).All the mice were received an injection of 0.2 mL corresponding reagent each week for 2 weeks.After 7 days since the second injection,T-SOD,GSH-Px activities,MDA content were detected with liver tissue of mice,and morphologic change were observed after making paraffin section.Compa... |
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| Keywords: | Citric acid Mice Liver Oxidative stress Toxicity |
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