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HYPERTROPHIC OSTEOPATHY ASSOCIATED WITH PULMONARY BLASTOMYCOSIS IN A DOG
Authors:Charles W  Brockus  DVM  John T  Hathcock  DVM  MS  Diplomate ACVR
Institution:Department of Small Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Auburn, AL 36849;Department of Radiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.
Abstract:Hypertrophic osteopathy (HO) associated with pulmonary blastomycosis was diagnosed in a 5–year-old male mixed-breed dog. One year prior to referral, increased pulmonary opacity had been identified on radiographs made during an examination for a chronic cough. Although serologic tests for blastomycosis were negative, the dog was treated with oral ketoconozole on the basis of suspicious lesions seen on radiographs and clinical signs. Ten months after completing the ketoconozole therapy, the dog was presented for a persistent cough and lameness. Intrapulmonary masses and periosteat proliferation were observed radiographically. A biopsy of the pulmonary masses was done, and Blastomyces dermatitidis was identified. Amphotericin B and ketoconozole administration resulted in clinical improvement and partial resolution of the HO lesions five months after initiation of therapy.
Keywords:hypertrophic osteopathy  blastomycosis
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