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Sequential Low-Dose Rate Half-Body Irradiation and Chemotherapy for the Treatment of Canine Multicentric Lymphoma |
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| Authors: | DM Lurie IK Gordon AP Théon CO Rodriguez SE Suter MS Kent |
| Institution: | Veterinary Medical Teaching Hospital, University of California, Davis, CA;;the Department of Surgical and Radiological Sciences, University of California, Davis, CA;;Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL;;Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC;and;Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD |
| Abstract: | Background: Sequential half-body irradiation (HBI) combined with chemotherapy is feasible in treating canine lymphoma, but prolonged interradiation intervals may affect efficacy. A 2-week interradiation interval is possible in most dogs receiving low-dose rate irradiation (LDRI) protocols at 6 Gy dose levels. Hypothesis: LDRI incorporated into a cyclophosphamide, doxorubicin, vincritine, and prednisone (CHOP)-based chemotherapy protocol is effective for the treatment of lymphoma in dogs. Animals: Thirty-eight client-owned animals diagnosed with multicentric lymphoma. Methods: Retrospective study evaluating the efficacy and prognostic factors for the treatment of canine lymphoma with sequential HBI and chemotherapy. Results: The median 1st remission was 410 days (95% confidence interval CI] 241–803 days). The 1-, 2-, and 3-year 1st remission rates were 54, 42, and 31%. The median overall survival was 684 days (95% CI 334–1,223 days). The 1-, 2-, and 3-year survival rates were 66, 47, and 44%. Conclusions and Clinical Relevance: Results of this study suggest that treatment intensification by a 2-week interradiation treatment interval coupled with interradiation chemotherapy is an effective treatment for dogs with lymphoma. |
| Keywords: | Combination therapy Dogs Efficacy |