| 人参皂苷-Rh2衍生物体外诱生小鼠细胞因子的作用及对NO水平的影响 |
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| 引用本文： | 郭志廷,伊鹏霏,褚秀玲,王鲁,韦旭斌.人参皂苷-Rh2衍生物体外诱生小鼠细胞因子的作用及对NO水平的影响[J].畜牧与兽医,2007,39(1):1-3. |
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| 作者姓名： | 郭志廷 伊鹏霏 褚秀玲 王鲁 韦旭斌 |
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| 作者单位： | 吉林大学畜牧兽医学院,吉林,长春,130062 |
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| 基金项目： | 国家自然科学基金项目（30471272）. |
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| 摘 要： | 探讨了经分子修饰后的人参皂苷-Rh2(衍生物)对小鼠脾T淋巴细胞分泌IL-2与IFNγ-、腹腔巨噬细胞分泌TNF-α与NO水平的影响。应用双抗体夹心ELISA法测定3种细胞因子的含量,硝酸还原酶法测定NO的含量。结果表明,衍生物的3个浓度(100,200和300μg/mL)均抑制了IL-2(P<0.01)和NO(P>0.05)的分泌,明显促进了IFN-γ和TNF-α的分泌(P<0.01)。提示衍生物可能是通过细胞因子途径来调节机体的免疫功能。
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| 关 键 词： | 人参皂苷-Rh2 细胞因子 分子修饰 衍生物 |
| 文章编号： | 0529-5130（2007）01-0001-03 |
| 修稿时间： | 2006-05-08 |
Effect of ginsenoside-Rh2 with molecular modification on secretion of cytokines and NO level in mouse in vitro |
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| GUO Zhi-ting,YI Peng-fei,CHU Xiu-ling,WANG Lu,WEI Xu-bin.Effect of ginsenoside-Rh2 with molecular modification on secretion of cytokines and NO level in mouse in vitro[J].Animal Husbandry & Veterinary Medicine,2007,39(1):1-3. |
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| Authors: | GUO Zhi-ting YI Peng-fei CHU Xiu-ling WANG Lu WEI Xu-bin |
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| Institution: | College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China |
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| Abstract: | Contents of IL-2 and IFN-γ secreted by spleen T lymphocyte and TNF-α and NO secreted by peritoneal macrophage from mice induced by ginsenoside-Rh2 with molecular modification(the derivate) were determined by DAS-ELISA or by nitrate reductase approachs.The results showed that secretion of IL-2(P<0.01) and NO(P>0.05) were inhibiteded,and secretion of IFN-γ and TNF-α were significantly enhanced by the derivate at concentrations ranging from 100 μg/mL to 300 μg/mL(P<0.01),suggesting that the derivate could regulate mouse immunologic function by the way of cytokines. |
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| Keywords: | ginsenoside-Rh2 cytokine molecular modification derivate |
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