| H9N2亚型禽流感疫苗株的筛选及其免疫效果评价 |
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| 引用本文： | 许传田,鲁梅,胡北侠,杨少华,颜世敢,张琳,张秀美.H9N2亚型禽流感疫苗株的筛选及其免疫效果评价[J].兽医大学学报,2012(7):997-1000. |
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| 作者姓名： | 许传田 鲁梅 胡北侠 杨少华 颜世敢 张琳 张秀美 |
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| 作者单位： | [1]山东省农业科学院畜牧兽医研究所,山东济南250100 [2]潍坊工程职业学院,山东青州262500 |
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| 基金项目： | 山东省博士基金资助项目（BS2009YY005）;现代农业产业技术体系建设专项资金资助项目（CARS-42-Z12） |
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| 摘 要： | 通过交叉血凝试验，疫苗备用毒株免疫SPF鸡后再用同源和异源毒株攻毒，评价疫苗备用毒株对SPF鸡保护效果。结果显示，H9N2疫苗备用株免疫SPF鸡后，再用H9亚型流感病毒流行株攻毒，SPF鸡咽喉和泄殖腔排毒量大大降低。结果表明，本试验筛选的疫苗备用毒株对H9N2亚型流感病毒具有一定的保护率，完全符合疫苗株要求。
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| 关 键 词： | H9N2禽流感 疫苗备用毒株 排毒量 |
H9N2 subtypes of flu vaccine strains selection and immune effect assessment |
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| Authors: | XU Chuan-tian LU Mei HU Bei-xia YANG Shao-hua YAN Shi-gan ZHANG Lin ZHANG Xiu-mei |
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| Institution: | 1. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Science, J inan 250100, China ; 2. Wei fang Engineering Vocational College, Qingzhou , Shandong 262500, China) |
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| Abstract: | H9N2 influenza vaccine viruses were selected from local epidemic strains, providing appropriate bird flu vaccine strain which were used to produce a vaccine. Through cross hemagglutination, and SPF chicken were im- muned by the vaccine spare strain,and then were tapped poison by homogenous and heterologous strain to evaluate protective effect of vaccine spare strain. SPF chicken immuned, viruses quantity let out is reduced greatly in throat and cloacae,after tapping poison with epidemic influenza virus. In this study, H9N2 vaccine spare strain has certain protection efficiency,and complies with the vaccine strains requirements completely. |
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| Keywords: | H9N2 avian influenza vaccine strain reserved excretion of viruses |
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