| 氯化镉对小鼠的急性毒性效应 |
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| 引用本文： | 杨雪峰,葛亚明,姜金庆,徐之勇,崔艳红,王自良.氯化镉对小鼠的急性毒性效应[J].兽医大学学报,2012(3):467-471. |
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| 作者姓名： | 杨雪峰 葛亚明 姜金庆 徐之勇 崔艳红 王自良 |
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| 作者单位： | 河南科技学院动物科学学院,河南新乡453003 |
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| 基金项目： | 河南省高等学校青年骨干教师资助计划资助项目（2010GGJS-136） |
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| 摘 要： | 采用Bliss法对小鼠经口灌胃氯化镉溶液（对照组0.0mg/kg;试验组Ⅰ～Ⅵ分别为98.3,122.9,153.6,192.0,240.0,300.0mg/kg）,并对染毒后小鼠的死亡情况、体质量、脏器指数、血液生理指标和病理剖检变化进行分析,以探讨氯化镉对小鼠的急性毒性效应。结果显示,氯化镉LD50为187.03mg/kg;小鼠的体质量随染毒剂量的增加而降低（P〈0.01）;与对照组相比,Ⅰ组小鼠心指数差异不显著（P〉0.05）,其余各组差异显著（P〈0.05）,脾指数和睾丸指数差异极显著（P〈0.01）,其余脏器指数均差异不显著（P〉0.05）;小鼠血液生理指标均在正常生理范围内波动（P〉0.05）;死亡小鼠除大脑组织无明显病变外,以Ⅵ组小鼠各组织的病变较严重,存活小鼠各组织的病变以Ⅰ组较轻微,Ⅴ组较严重。结果表明,氯化镉属于中等毒性物质,对小鼠多个组织均具有不同程度的急性毒性效应。
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| 关 键 词： | 氯化镉 小鼠 半数致死量 毒性效应 |
Acute toxic effect of cadmium chloride in mice |
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| Authors: | YANG Xue-feng GE Ya-ming JIANG Jin-qing XU Zhi-yong CUI Yan-hong WANG Zi-liang |
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| Institution: | (College of Animal Science,Henan Institute of Science and Technology,Xinxiang,Hennan 453003,China) |
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| Abstract: | Mice were orally administered with cadmium chloride（the control group：0.0 mg/kg;the test groups Ⅰ-Ⅵ：98.3,122.9,153.6,192.0,240.0,300.0 mg/kg,respectively） to carry out acute toxicity test by Bliss method,and then these indexes such as death rate,body weight,organ relative index,blood physiological index,necropsy and histopathology were analyzed.The results showed that the LD50 of cadmium chloride in mice was 187.03 mg/kg.The body weight gain of mice was cut down with the dosage raising of cadmium chloride（P0.01）.Compared with the control group,the difference of the cardiac relative index in Ⅰgroup was not significant（P0.05）,but it was significant（P0.05） in the other groups,the difference of the testis and the spleen relative index were highly significant（P0.01）,and the relative indexes of the rest organs were no significant difference（P0.05）.The blood physiological index fluctuated in normal ranges（P0.05）.In the dead mice of the each group except that the cerebrum tissue had not obviously pathological changes,the rest tissues all had the pathological changes,especially in Ⅵ group.In the survival mice the pathological changes of the tissues were slighter in Ⅰ group and more severe in Ⅴ group than other groups.The results suggested that cadmium chloride was the medium intensity toxic substance and it could produce the different degree acute toxic effects in some tissues of mice. |
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| Keywords: | cadmium chloride mice half lethal dose toxic effect |
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