| 甘草查尔酮E对金黄色葡萄球菌的抗菌活性 |
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| 引用本文： | 邱家章,邓旭明,罗永煌.甘草查尔酮E对金黄色葡萄球菌的抗菌活性[J].兽医大学学报,2012(8):1194-1198. |
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| 作者姓名： | 邱家章 邓旭明 罗永煌 |
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| 作者单位： | [1]西南大学药学院,重庆北碚400716 [2]重庆市兽药工程技术研究中心,重庆北碚400716 [3]吉林大学畜牧兽医学院,吉林长春130062 |
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| 基金项目： | 重庆市科技创新能力建设资助项目（CSTC,2009CB1010） |
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| 摘 要： | 应用肉汤微量稀释法测定甘草查尔酮E对金黄色葡萄球菌（简称金葡菌）的抗菌活性,并通过溶血试验、Western blot分析和荧光定量PCR试验考察亚抑菌浓度的甘草查尔酮E对金葡菌α-溶血素表达的影响。结果显示,甘草查尔酮E对7株金葡菌的最低抑菌质量浓度为2～8mg/L;亚抑菌浓度的甘草查尔酮E能显著降低金葡菌α-溶血素的表达,且呈现剂量依赖性。
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| 关 键 词： | 金黄色葡萄球菌 甘草查尔酮E 亚抑菌浓度 α-溶血素 |
Antibacterial activity of licochalcone E on Staphylococcus aureus |
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| Authors: | QIU Jia-zhang ＇ DENG Xu-ming LUO Yong-huang |
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| Institution: | 1＇2 (1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China ; 2. Chongqing Engineering Technology Research Centre of Veterinary Drug, Chongqing 400716, Chinas3. College of Animal Science and Veterina- ry Medicine ,Jilin University ,Changchun 130062, China) |
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| Abstract: | A broth micro-dilution method was used to investigate the antimicrobial activity of licochaleone E against Staphylococcus aureus,and the influence of sub-inhibitory concentrations of licochalcone E on the expression of a- toxin by S. aureus was assessed by hemolysis assay,Western blot and real-time RT-PCR. The MICs of licochalcone E against 13 S. aureus strains were ranged from 2 to 8 mg/L;The production of a-toxin in S. aureus was reduced by sub-inhibitory concentrations of licochalcone E in a dose-dependent manner. |
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| Keywords: | Staphylococcus aureus licochalcone E sub-inhibitory concentrations a-toxin |
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