New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
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| Authors: | Michael P Gotsbacher Peter Karuso |
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| Institution: | Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia; E-Mail: |
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| Abstract: | Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites. |
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| Keywords: | alkaloid bromotyrosine Pseudoceratina sponge Tylodina antibiotics marine natural products |
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