| 细胞渗透肽在动物医学领域的应用 |
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| 引用本文： | 王娜,张厚双.细胞渗透肽在动物医学领域的应用[J].动物医学进展,2010,31(12). |
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| 作者姓名： | 王娜 张厚双 |
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| 作者单位： | 1. 中国农业科学院上海兽医研究所农业部动物寄生虫学重点实验室,上海,200241;延边大学农学院,吉林龙井,133400
2. 中国农业科学院上海兽医研究所农业部动物寄生虫学重点实验室,上海,200241 |
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| 摘 要： | 随着疫苗及药物的发展,新型传递系统的研究和应用日益受到关注。细胞渗透蛋白或肽(CPPs)作为一种传递系统,具有穿过哺乳动物细胞膜的能力,且不受能量和受体的约束。细胞渗透肽已经成功地携带多肽、荧光标记蛋白、螯合剂、DNA、反义核酸、脂质体等物质,实现体内外的跨膜递送,并可导入几乎所有的组织和细胞内。细胞渗透肽作为转运载体在药物传递、治疗性分子转运和疫苗增效方面都显示了重要价值,已成为国内外相关研究的一个热点。论文对细胞渗透肽的种类和在动物医学方面的应用做了综合性的概述,以此促进细胞渗透肽能在将来的动物医学方面有更广阔的应用前景。
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| 关 键 词： | 细胞渗透肽 TAT ANTP VP22 动物医学 应用 |
Application of Cell Penetrating Peptides in Veterinary Medicine |
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| WANG Na,ZHANG Hou-shuang.Application of Cell Penetrating Peptides in Veterinary Medicine[J].Progress In Veterinary Medicine,2010,31(12). |
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| Authors: | WANG Na ZHANG Hou-shuang |
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| Institution: | WANG Na1,2,ZHANG Hou-shuang1(1.Key Laboratory of Animal Parasitology of Ministry of Agriculture,Shanghai Veterinary Research Institute,CAAS,Shanghai,200241,China,2.Agricultural College of Yanbian University,Longjing,Jilin,133400,China) |
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| Abstract: | With the development of vaccine and drug,the study and application of novel delivery system is critial.Cell penetrating proteins or peptides(CPPs) have the ability to cross the cytomembrane of mammalian cells in an apparently energy-and receptor-independent fashion.Cell penetrating peptides have been successfully carried peptides,fluorescent marker protein,chelating agents,DNA,antisense nucleic acids,liposomes and others into all tissues and cells in vivo or in vitro.Cell penetrating peptides as transpoters... |
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| Keywords: | cell penetrating peptide TAT ANTP VP22 veterinary medicine application |
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