| 药用鼠尾草二萜醌类及有关中药单体对羟自由基的清除效能 |
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| 引用本文： | 薛明,汪汉卿.药用鼠尾草二萜醌类及有关中药单体对羟自由基的清除效能[J].中国兽药杂志,1999,33(3):15-18. |
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| 作者姓名： | 薛明 汪汉卿 |
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| 作者单位： | 中国农业科学院中兽医研究所农业部新兽药工程重点开放实验室!兰州730050，中国农业科学院中兽医研究所农业部新兽药工程重点开放实验室!兰州730050，中国科学院兰州化学物理研究所，中国农业科学院中兽医研究所农业部新兽药工程重点开放实验室!兰州730050，中国农业科学院中兽医研 |
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| 基金项目： | “九五”国家重点科技攻关项目 |
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| 摘 要： | 采用电子自旋共振和自旋捕集技术，观察药用鼠尾草丹参二萜醌类化合物及其它中草药中有关单体化合物对Ｆｅｎｔｅｎ 反应产生的羟自由基的清除效能。结果表明，试验浓度的二萜醌类化合物对羟自由基有不同程度的清除作用，其中对醌类的抑制作用强于邻醌类。含多羟基醌类化合物具有较强的清除效能，分子中的羟基对消除自由基有促进作用。在一定浓度范围内，隐丹参酮对羟自由基有较好的清除作用。
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| 关 键 词： | 电子自旋共振 羟自由基 药用鼠尾草二萜醌 中药 |
Scavenging Effect of Diterpenoid Tanshinones and Some Natural Products on Hydroxyl Free Radicals |
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| XUE Ming,CUI Yin,WANG Han\|qin,et al.Scavenging Effect of Diterpenoid Tanshinones and Some Natural Products on Hydroxyl Free Radicals[J].Chinese Journal of Veterinary Drug,1999,33(3):15-18. |
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| Authors: | XUE Ming CUI Yin WANG Han\|qin |
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| Abstract: | With the use of the spin trapping methods, the scavenging effects of diterpenoid tanshinones from the roots of Salvia Przewalskii and smoe related pigments from Chinese traditional herbs are studied. In Fenten Reaction, Diterpenoid tanshnones have the different scavenging effect (53%~82%), para quinones have the stronger scavenging effects than ortho quinones. The hydroxyl radical in the molecular bone has been proved as the inhibition group on OH. The relationship between the compound structure and scavenging the free radical activities was also discussed. |
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| Keywords: | Spin trapping method hydroxyl free radicals Diterpenoid tanshinones Chinese traditional herbs |
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