| 地参多糖对D-半乳糖所致衰老小鼠的抗氧化作用研究 |
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| 引用本文： | 林春榕,左绍远,熊伟,陈贵元.地参多糖对D-半乳糖所致衰老小鼠的抗氧化作用研究[J].安徽农业科学,2012(18):9646-9647. |
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| 作者姓名： | 林春榕 左绍远 熊伟 陈贵元 |
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| 作者单位： | 大理学院基础医学院,云南大理,671000;大理学院基础医学院,云南大理,671000;大理学院基础医学院,云南大理,671000;大理学院基础医学院,云南大理,671000 |
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| 基金项目： | 云南省科技厅高新技术科技计划项目，大理学院青年科研基金 |
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| 摘 要： | 目的]研究地参多糖(LLP)对D-半乳糖所致衰老小鼠的抗氧化作用。方法]取昆明种小白鼠50只,随机分为5组。除正常对照组外,其余各组每天于颈背皮下注射D-半乳糖80 mg/kg,连续42 d,造成亚急性衰老模型。在注射D-半乳糖的同时,试验组每天分别灌胃给予地参多糖(LLP)300、200和100 mg/kg,正常对照组及模型对照组给予等量生理盐水。末次给药12 h后,分离血清及肝组织,分别测定各组小鼠衰老相关生化指标。结果]LLP能拮抗D-半乳糖所致的小鼠衰老,使小鼠血清及肝组织SOD和GSH-Px活性明显回升,MDA的水平下降。结论]LLP具有一定的抗氧化和抗衰老作用。
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| 关 键 词： | 地参多糖(LLP) D-半乳糖 衰老小鼠 抗氧化 |
Antioxidation Effects of Lycopus Lucidus polysaccharides on Aged Mice Induced by D-Galactose |
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| Institution: | LIN Chun-rong et al(College of Basic Medicine,Dali University,Dali,Yunnan 671000) |
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| Abstract: | Objectives] To research the antioxidation effects of Lycopus Lucidus polysaccharides(LLP) on aged mice induced by D-galactose.Method] A total of 50 Kunming mice were randomly divided into 5 groups.Except for the normal control group,mice in other groups were given 80 mg/kg D-galactose by subcutaneous injection at the neck back for 42 d,so as to establish the sub-acute aged model.At the same time of D-galactose injection,mice in experimental groups were given 300,200 and 100 mg/kg LLP by gavage;and mice in normal control group and model group were given the same volume of normal saline by gavage.After 12 h of the last administration,mice serum and liver tissues were separated;and aging related biochemistry indexes were detected.Result] LLP had antagonism effects to the mice aging induced by D-galactose,significantly enhance the SOD and GSH-Px activities in mice serum and liver tissues,and reduce the MDA content.Conclusion] LLP may have certain anti-oxidation and anti-aging effects. |
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| Keywords: | Lycopus Lucidus polysaccharide(LLP) D-galactose Aged mice Anti-oxidation |
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