| 六溴环十二烷短期暴露对红鳍笛鲷幼鱼甲状腺激素T3和T4含量的影响 |
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| 引用本文： | 陈海刚,孙立伟,张林宝,张喆,胡莹,蔡文贵,贾晓平.六溴环十二烷短期暴露对红鳍笛鲷幼鱼甲状腺激素T3和T4含量的影响[J].农业环境科学学报,2016,35(7):1257-1263. |
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| 作者姓名： | 陈海刚 孙立伟 张林宝 张喆 胡莹 蔡文贵 贾晓平 |
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| 作者单位： | 1. 中国水产科学研究院南海水产研究所,广东省渔业生态环境重点实验室,农业部南海渔业资源开发利用重点实验室,农业部南海渔业资源环境科学观测实验站,广州510300;2. 浙江工业大学海洋学院,杭州,310032 |
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| 基金项目： | 国家自然科学基金项目（41306113）；中央级公益性科研院所基本科研业务费专项资金项目（2014TS11）；广东省渔业生态环境重点实验室开放基金课题（GDKL2012001，LFE-2013-2）；农业部南海渔业资源开发利用重点实验室开放基金课题（LSF2011-06） |
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| 摘 要： | 为研究六溴环十二烷(HBCD)短期暴露对红鳍笛鲷的甲状腺素干扰效应及相关机理,实验室条件下分别将红鳍笛鲷幼鱼暴露于3个不同浓度的HBCD(8.6、43.0、215μg·L-1)溶液中24、48、96 h后,以肝脏和脑组织中三碘甲腺原氨酸(T3)和四碘甲腺原氨酸(T4)含量及T3/T4比值为生物标志物,评价HBCD短期暴露对红鳍笛鲷肝、脑组织甲状腺功能的影响。结果表明,HBCD对红鳍笛鲷幼鱼肝、脑组织甲状腺具有明显的干扰作用,且8.6、43.0μg·L-1浓度暴露下对T3、T4含量以诱导作用为主,215μg·L-1浓度暴露下短时间内表现为极显著的诱导作用(P0.01),随暴露时间延长则表现为极显著的抑制作用(P0.01)。此外,HBCD暴露过程中,肝组织T3/T4比值均极显著低于对照组(P0.01),且呈明显的时间-效应和剂量-效应关系;脑组织T3/T4比值则随暴露浓度和暴露时间呈现较大差异,主要表现为短时间暴露T3/T4比值高于对照组、长时间暴露T3/T4比值低于对照组。研究表明,红鳍笛鲷肝脏和脑组织甲状腺素T3、T4含量及T3/T4比值对实验室3种浓度的HBCD胁迫均具有足够的灵敏度,在一定程度上可为环境中甲状腺激素干扰物的筛选和生态风险评价提供重要的科学依据。
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| 关 键 词： | 六溴环十二烷 红鳍笛鲷 甲状腺素 三碘甲腺原氨酸 四碘甲腺原氨酸 |
| 收稿时间： | 2016/1/26 0:00:00 |
Effects of short-term exposure to hexabromocyclododecane (HBCD)on T3 and T4 of liver and brain in juvenile crimson snapper (Lutjanus erythopterus) |
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| CHEN Hai-gang,SUN Li-wei,ZHANG Lin-bao,ZHANG Zhe,HU Ying,CAI Wen-gui and JIA Xiao-ping.Effects of short-term exposure to hexabromocyclododecane (HBCD)on T3 and T4 of liver and brain in juvenile crimson snapper (Lutjanus erythopterus)[J].Journal of Agro-Environment Science( J. Agro-Environ. Sci.),2016,35(7):1257-1263. |
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| Authors: | CHEN Hai-gang SUN Li-wei ZHANG Lin-bao ZHANG Zhe HU Ying CAI Wen-gui and JIA Xiao-ping |
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| Institution: | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China,Ocean College, Zhejiang University of Technology, Hangzhou 310032, China,South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China,South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China,South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China,South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China and South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;Key Laboratory of Fishery Ecology Environment, Guangdong Province;Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture;Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China |
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| Abstract: | |
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| Keywords: | hexabromocyclododecane Lutjanus erythopterus thyroid hormone triiodothyronine thyroxin |
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