Evaluation of serum cystatin-C in dogs with visceral leishmaniasis |
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| Authors: | S Pasa G Bayramli A Atasoy A Karul S Ertug S Ozensoy Toz |
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| Institution: | (1) Department of Internal Medicine, Faculty of Veterinary Medicine, Adnan Menderes University, Aydin, Turkey;(2) Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey;(3) Department of Parasitology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey;(4) Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey |
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| Abstract: | Serum Cystatin C (sCys-C) is one of the most important serum markers of renal function assessment in dogs. The purpose of
this study was to determine the sCys-C concentration in dogs with visceral leishmaniasis (VL). In the study, 16 dogs with
VL and 10 clinical healty dogs (control) were used. Mean sCys-C concentration of the infected dogs was significantly higher
than that of the control group (p < 0.05). Mean serum creatinine concentration was lower and mean blood urea nitrogen, albumin
and globulin concentrations were higher in dogs with VL; however, these changes were not statistically significant. Mean total
protein and phosphorus concentrations were found to be higher in dogs with VL than healthy dogs (p < 0.05). No significant
correlation had been determined between sCys-C and other variables. Visceral leishmaniasis in dogs has increased sCys-C concentration
indicating a possible renal impairment; however, further studies are needed to be performed together with renal biopsies in
the investigation sCys-C in dogs with VL. |
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| Keywords: | Visceral leishmaniasis Dog Serum cystatin C Renal failure |
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