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| 药物美沙拉秦合成工艺的改进 | |
| 引用本文： | 张昌军,陈小全,周秀艳,左之利,邵辉莹.药物美沙拉秦合成工艺的改进[J].山东农业大学学报(自然科学版),2006,37(2):225-226,230. |
| 作者姓名： | 张昌军 陈小全 周秀艳 左之利 邵辉莹 |
| 作者单位： | 1. 泰山医学院化学与化学工程学院,山东泰安,271000 2. 四川大学化工学院,四川成都,610065 3. 中国科学院上海药物研究所,上海,201203 |
| 摘 要： | 合成新药5-胺基-2-羟基苯甲酸（美沙拉秦）。以邻羟基苯甲酸的钠盐为原料，在超声波作用下合成药物5-胺基-2-羟基苯甲酸。通过与文献报道路线的对比，可知在超声波作用下的合成路线能够节省时间，提高回收率等优点。此法适用于合成新药5-胺基-2-羟基苯甲酸。 |
| 关 键 词： | 美沙拉秦(5-胺基-2-羟基苯甲酸) 合成 水杨酸钠 超声波 |
| 文章编号： | 1000-2324（2006）02-0225-02 |
| 收稿时间： | 2005-08-18 |
| 修稿时间： | 2005-08-18 |
THE NEW SYNTHESIS METHOD OF MESALAZINE |
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| ZHANG Chang-jun,CHEN Xiao-quan,ZHOU Xiu-yan,ZUO Zhi-li,SHAO Hui-ying.THE NEW SYNTHESIS METHOD OF MESALAZINE[J].Journal of Shandong Agricultural University,2006,37(2):225-226,230. | |
| Authors: | ZHANG Chang-jun CHEN Xiao-quan ZHOU Xiu-yan ZUO Zhi-li SHAO Hui-ying |
| Institution: | 1. Chemistry and Chemical Engineering School,Taishan Medical University,Taian 271000 China 2. Chemical Engineering School,Sichuan University,Chengdu 610065,China; 3. Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China |
| Abstract: | A new synthesis route for 5-aminosalicylic acid was studied by the treatment of the sodium with nitric acid under ultrasound. This new synthesis route was shorter in time. easy control and higher yield in contranst with the others. This new synthesis route is feasible to the preparation of 5-aminosalicylic acid. |
| Keywords: | Mesalazine(5-aminosalicylic acid) Synthesis Sodium salicylic acid Ultrasound |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |