Ruminal Metabolism in Sheep of Saponins from Yucca schidigera |
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| Authors: | Flåøyen A Wilkins AL Sandvik M |
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| Institution: | (1) National Veterinary Institute, PO Box 8156 Dep., N-0033 Oslo, Norway;(2) Department of Large Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep., N-0033 Oslo, Norway;(3) Chemistry Department, School of Science and Technology, The University of Waikato, Private Bag 3105, Hamilton, New Zealand |
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| Abstract: | Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was killed 5 h after the last dose and GC-MS analysis of the free and conjugated sapogenin content samples of liver, and of the contents of the rumen, omasum, abomasum, duodenum, jejunum, ileum, colon and rectum, of faecal samples collected before dosing started, and of parts of the administered Yucca saponin were performed. The Yucca material contained mainly sarsasapogenin and smilagenin saponins. Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. The absorption of free sapogenins appeared to occur in the jejunum. The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant. |
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| Keywords: | phytotoxins saponins sapogenins sheep Yucca schidigera |
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