Ultrastructural localization of pemphigus vulgaris antigen on canine keratinocytes in vivo and in vitro |
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| Authors: | M M Suter J E Wilkinson E P Dougherty R M Lewis |
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| Institution: | Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853. |
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| Abstract: | Pemphigus antigens were localized, by use fo immunoelectron microscopy, on canine keratinocytes in vivo on esophageal mucosa and in vitro on established cultured keratinocytes. Convalescent sera from a human being with pemphigus vulgaris and a human being with pemphigus foliaceus reacted with the interdesmosomal cytoplasmic keratinocyte membrane of canine esophagus. Cultured canine keratinocytes expressed the pemphigus vulgaris antigen in a similar pattern, but did not carry the pemphigus foliaceus antigen. The differential presence of cell surface antigens and its relation to various forms of the disease are discussed. |
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