Basic fibroblast growth factor and Alzheimer's disease |
| |
| Authors: | ZHU Da-ming HONG An LIN Jian |
| |
| Institution: | Bioengineering Institute of Jinan University, Guangzhou 510632, China |
| |
| Abstract: | Alzheimer's disease (AD), which is one type of senile deimentia,has three remarkable pathologic characteristics-senile plaque, neurofibrillar tangles and neuronal death. As a neurotrophic factor, basic fibroblast growth factor (bFGF) is closely related to AD. This art icle reviewed the interaction between bFGF and AD-associated gene products (such as amyliod protein, presenilin, apoloprotein E and microtubulin-associated protein tau) and neuronal apoptosis. Some researchers suggested that bFGF may be put forward as potential therapeutic agent in AD and play a role in preventing or retarding the pathological process of this disease, alleviating or even eradicat ing the pathological insults of this disease. |
| |
| Keywords: | Alzheimer disease Fibroblast growth factor basic Cells Apoptosis Proteins |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
