Expression of undulin in experimental rat liver fibrosis |
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| Authors: | YAO Ding-kang LI Shi KONG Xian-tao YE Ting-jun |
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| Institution: | Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China |
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| Abstract: | AIM: To observe the expression of undulin (Un) in liver tissue and to clarify the diagnostic significance of serum Un in experimental rat liver fibrosis. METHODS: Rat liver fibrosis was induced by carbon tetrachloride. The expression of Un in liver tissue was detected by immunohistochemical method. Serum Un levels was measured by enzyme immunoassay. RESULTS: Expression of Un increased in fibrotic liver than normal liver, and it was mainly distributed in portal tract stroma, central veins and fibrotic septa in fibrotic liver. Also, the level of serum Un was significantly higher in fibrotic liver than normal liver. CONCLUSION: These data suggest that Un should be a component of the hepatic extracellar matrix, and its expression could be increased greatly in fibrotic rat liver. Serum Un levels may be used as an indicator in liver fibrosis diagnosis. |
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| Keywords: | Liver cirrhosis Carbon tetrachloride Rats |
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