The protective effect of preconditioning on rabbit liver during ischemia and reperfusion and its potential mechanism |
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| Authors: | WANG Wan-tie LIN Li-na XU Zheng-jie LI Dong FAN Zhou-xi WANG Zhong-min |
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| Institution: | Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325003, China |
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| Abstract: | AIM:To investigate the protective effect of preconditioning on rabbit liver during total ischemia and reperfusion and its mechanism. METHODS: Using hepatic ischemia and reperfusion injury (HIRI) model in rabbits, animals were randomly divided into three groups: control group (A), non-preconditioning group(B) and preconditioning group(C), different effects of preconditioning on several parameters including alanine aminotransferase (ALT) activity and levels of nitric oxide (NO) and malondialdehyde (MDA) in plasma or liver tissue as well as hepatocellular morphological changes were measured and observed during HIRI. RESULTS:In C group NO levels of plasma and liver tissue were higher than those in B group (P＜0.05);While MDA levels and ALT value in plasma were lower than those in B group (P＜0.05 and P＜0.01); and there were not significant differences between C and A group (P＞0.05); abnormal morphological chages of liver cells in A group were ameliorated remarkably too during HIRI. CONCLUSION:Preconditioning can attenuate HIRI by improving NO level and reducing oxygen free radicals level. |
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| Keywords: | Liver Reperfusion injury Nitric oxide Oxygen Free radicals |
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